Seong-Hoon Park Selected Research

Sirtuin 2

11/2018	Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.
4/2017	Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
12/2016	SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
2/2016	ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
1/2016	SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
8/2013	SIRT2 directs the replication stress response through CDK9 deacetylation.
6/2012	SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.
10/2011	SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

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Seong-Hoon Park Research Topics

Disease

21	Neoplasms (Cancer) 01/2019 - 03/2008
7	Carcinogenesis 01/2019 - 01/2011
6	Lung Neoplasms (Lung Cancer) 07/2013 - 12/2009
3	Genomic Instability 01/2018 - 01/2010
2	Inflammation (Inflammations) 11/2018 - 04/2017
2	Fibrosis (Cirrhosis) 11/2018 - 11/2014
2	Neuroblastoma 01/2018 - 04/2009
2	Ataxia Telangiectasia (Louis Bar Syndrome) 02/2016 - 08/2013
2	Atrial Fibrillation 11/2014 - 03/2011
2	Malignant Pleural Effusion 03/2013 - 02/2012
1	Non-alcoholic Fatty Liver Disease 12/2018
1	Pancreatitis 11/2018
1	Iron Deficiencies 04/2017
1	Acute Kidney Injury (Acute Renal Failure) 03/2016
1	Diabetes Mellitus 03/2016
1	Colonic Neoplasms (Colon Cancer) 01/2016
1	Organizing Pneumonia 11/2014
1	Fatigue 10/2014
1	Prostatic Neoplasms (Prostate Cancer) 06/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 07/2013
1	Pleural Effusion (Pleural Effusions) 02/2012
1	Carcinoma (Carcinomatosis) 01/2012
1	Ovarian Neoplasms (Ovarian Cancer) 01/2012
1	Aneuploidy (Aneuploid) 10/2011
1	Hepatocellular Carcinoma (Hepatoma) 01/2011
1	Infections 12/2010
1	False Aneurysm (Pseudoaneurysm) 12/2009
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2009
1	Renal Cell Carcinoma (Grawitz Tumor) 07/2008
1	Adenocarcinoma 03/2008
1	Stomach Neoplasms (Stomach Cancer) 03/2008
1	Necrosis 04/2007
1	Hypoxia (Hypoxemia) 04/2007

Drug/Important Bio-Agent (IBA)

8	Sirtuin 2IBA 11/2018 - 10/2011
6	SirtuinsIBA 01/2018 - 01/2011
5	Sirtuin 3IBA 01/2017 - 01/2010
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 01/2011
3	Superoxides (Superoxide)IBA 01/2011 - 01/2010
2	Superoxide DismutaseIBA 01/2019 - 01/2010
2	Phosphotransferases (Kinase)IBA 02/2016 - 06/2014
2	Small Interfering RNA (siRNA)IBA 06/2014 - 07/2013
2	CaspasesIBA 07/2013 - 04/2007
2	AlbuminsIBA 01/2013 - 01/2011
2	Proteins (Proteins, Gene)FDA Link 02/2012 - 01/2011
2	Estrogens (Estrogen)FDA Link 01/2012 - 01/2011
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/2018
1	CeruletideIBA 11/2018
1	Pyruvate KinaseIBA 01/2016
1	Protein Isoforms (Isoforms)IBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 01/2016
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2016
1	APTIBA 11/2014
1	Amiodarone (Amiodarona)FDA LinkGeneric 11/2014
1	Carbon MonoxideIBA 11/2014
1	Oxidoreductases (Dehydrogenase)IBA 11/2014
1	Pyruvic Acid (Pyruvate)IBA 11/2014
1	BI 2536IBA 06/2014
1	Lysine (L-Lysine)FDA Link 08/2013
1	Cyclin TIBA 08/2013
1	Cyclin-Dependent Kinase 9IBA 08/2013
1	Docetaxel (Taxotere)FDA Link 07/2013
1	Sulindac (Copal)FDA LinkGeneric 07/2013
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 07/2013
1	Simvastatin (Zocor)FDA LinkGeneric 07/2013
1	C-Reactive ProteinIBA 03/2013
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2013
1	SurvivinIBA 02/2012
1	Tumor Biomarkers (Tumor Markers)IBA 02/2012
1	antigen CYFRA21.1IBA 02/2012
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 01/2012
1	Tamoxifen FDA LinkGeneric 01/2012
1	Progesterone FDA LinkGeneric 01/2012
1	Eosine Yellowish-(YS) (Eosin)IBA 04/2011
1	Hematoxylin (Haematoxylon)IBA 04/2011
1	Brain Natriuretic Peptide (Natrecor)FDA Link 03/2011
1	GadoliniumIBA 01/2011
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2011
1	diethylenetriamineIBA 01/2011
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2011
1	gadolinium ethoxybenzyl DTPA FDA Link 01/2011
1	PENTAIBA 01/2011
1	Free RadicalsIBA 01/2011
1	Sirtuin 1IBA 04/2009
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 04/2009
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 04/2009
1	Biotin (Vitamin H)FDA Link 03/2008
1	StreptavidinIBA 03/2008
1	Carcinoembryonic AntigenIBA 03/2008
1	Peroxidase (Myeloperoxidase)IBA 03/2008
1	Caspase 3 (Caspase-3)IBA 04/2007
1	CalpainIBA 04/2007
1	calpain inhibitorsIBA 04/2007

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 01/2013 - 12/2009
1	Artificial Respiration (Mechanical Ventilation) 03/2016
1	Therapeutics 01/2016
1	Acupuncture Therapy 10/2014
1	Acupuncture Points (Acupuncture Point) 10/2014
1	Chemoprevention 07/2013
1	Radiofrequency Ablation 07/2008